Canadian Health&Care Mall Chooses the Best Antidepressant in 2016
To say the obvious thing, the main purpose of antidepressants is treatment of depression. Antidepressants are generally recommended as the first-line therapy for mild to severe depressive disorders, when used in combination with psychotherapy, such as cognitive-behavioral talk. Unfortunately, depression became the most dangerous psychological disorder of the 21st century. Luckily, for all 16 millions of Americans who suffer from at least one major depressive disorder can treat their condition with legally approved and effective antidepressants. In 2016 Canadian Health&Care Mall users asked our experts to conduct a research on the topic of the most prescribed antidepressants – to compare and define the best from the best antidepressant pills. You asked, we obeyed and right now offer the comparison of the most popular at our website pills for treating major depressive disorder.
Canadian Health&Care Mall informs: when do you actually need to use antidepressants?
Antidepressants can be applied to cure mental disorders and disturbances like:
- obsessive-compulsive disorder;
- anxiety disorder;
- panic disorder;
- strong phobias such as agoraphobia and social phobia;
- post-traumatic stress disorder.
There are cases when depression occurs as a side effect of different sexual disorders – in these cases, therapists or doctors advise to visit psychotherapy sessions. In all these cases certain pills can ease the symptoms of major depression.
Remember that:
- One can easily find an antidepressant that is suitable for him/her personally;
- 6 out of 10 people feel better after application of the first chosen antidepressant. Others will try different antidepressants to find the right one;
- All antidepressants have their pros and cons, and until you start to use any of them, you will not know for sure whether the drug will be able to help you in the fight against depression;
- Antidepressants are classified according to the types of neurotransmitters and they affect in different ways.
Canadian Health and Care Mall: the most common types of antidepressants
According to the multiple reviews received from Canadian Health&Care Mall users, our team of medical experts managed to define the most popular drug groups of antidepressants with brand and generic titles that were ordered via our daily deals in the first half of 2016. It turns out that the most popular antidepressants with the highest rate of positive feedback are:
- Selective serotonin reuptake inhibitors
The SSRIs remained the most common group of prescribed antidepressants in the U.S. and Canada since the mid-1980s until the 2000s. These antidepressants block the return of serotonin back into presynaptic cells (that send a nerve impulse). This action of SSRIs increases the concentration of serotonin in synaptic junctions between nerve cells, in such way enhancing stimulation of postsynaptic receiving pulse cells. All SSRIs are equally effective and tolerated in the same way.
The most popular antidepressants of this group that are still commonly recommended by therapists in the United States and Canada are Fluoxetine (Prozac), sertraline (Zoloft) and escitalopram (Lexapro).
Read also: List of Bestselling Drugs in Canada in 2015 – www.medscape.com/viewarticle/844317
- Tricyclic antidepressants
At first these drugs went on sale in the late 1950-early 1960s. Like SSRIs, these medications inhibit a neurotransmitter reuptake (noradrenaline) in a presynaptic nerve cell, in such way increasing its unlimited concentration.
Tricyclic antidepressants affect a person’s heart rate and blood pressure, as norepinephrine activity is involved in autonomic control by CNS of these functions. Drugs in this group are rarely used because of their toxicity and danger of overdose.
The most popular tricyclic antidepressants (watch full list on Drugs.com) in the United States and Canada in 2015 were amitriptyline (Elavil) and Clomipramine (Anafranil).
- Serotonin-norepinephrine reuptake inhibitor (SNRIs)
These antidepressants mid-1990s. Their action is based on blocking reuptake of both serotonin and norepinephrine inhibitors.
Most of SNRIs were approved for curing adult patients who suffer from major depressive disorder. Side effects of these drugs are similar to the side effects of the SSRIs, but expressed much weaker. Bupropion and Duloxetine, in particular, have minimal side effects in terms of sexual dysfunction and weight gain.
Bupropion (Zyban, Wellbutrin) which blocks the reuptake of dopamine and norepinephrine, Duloxetine (Cymbalta) and Desvenlafaxine (Pristiq) are the most popular antidepressants in this group.
If we appeal to “dry” statistical data, we should mention that the most prescribed antidepressant in the United States is Cymbalta with more than 11 millions of official prescriptions per year. CHCM users agree with this choice and 99% of all Cymbalta reviews at our site are positive. Surprisingly, another drug from this group – Pristiq- occupies the second place with 8.5 millions of prescriptions per year. Celexa and Zoloft follow this list of the leaders. No matter what drug you will choose for your treatment the most important recommendation from us – treat your depression just like any other disorder. About 80% of all people who suffer from different depressive disorders do not go through any treatment and continue to develop their condition to worse. Life can be great even if it seems gloomy right now. Stay positive!